Who are the gamblers? Our leaders at many levels, including those managing our workplaces, towns, cities, counties, and states, continue to underestimate the potential outcomes of COVID variant emergence. What many molecular biologists (scientists who work with DNA and RNA) and mathematicians understand is that the very nature of viral replication makes viruses into ever-changing evolution machines. The strain of COVID19 now running rampant through our network of unvaccinated neighbors is far more infective than the ones we dealt with in early 2020. This is the how and why.